#pyoderma gangrenosum

[fantailandfern]

Study day today.

I'm still getting over a cold, so I'm studying from home today.

Today's goals:

Finish up module on kaupapa Māori approaches to research

Start next module on intergenerational trauma in education

Start editing work so far and update portfolio

[batwynn]

My dermatologist laughing when I told him taking a simple shower triggered my autoimmune disease to the point where I had 20+ blisters/potential wounds pop up and telling me to “be more careful” was my last fucking straw after years of his mistreatment and refusing to classify my disabling and chronic disease as a fucking disability.

Letter to the office sent with file request. Official complaint to the medical board drafted and ready to go.

[sodaacrush]

URGENT!! PLEASE READ/SHARE 🚑‼️📢

My parents have started a GoFundMe for my mothers medical expenses because insurance doesn't cover all of her medicines, supplies to wrap her deep wounds, or hospital bills anymore. My mother is disabled and requires constant medical care. I'm begging you to spread this as far as you can!! Even just sharing the link helps! https://www.gofundme.com/f/4hu3ma-uncovered-medical-costs?utm_campaign=p_lico+share-sheet&utm_medium=copy_link&utm_source=customer

[chronically-crying]

me when i'm tired n just wanna go to bed: maybe I'll be fine if i don't do my wound care for one day.

also me: *can not sleep comfortably unless i do my wound care because my wounds are in the point of healing now where if they're uncovered it's super uncomfy*

[bluesidedown]

gotta say it's a bit weird to have a chunk of skin about an inch square on ur shoulder where all the nerves are apparently dead

[does-truth-matter]

The CDC has quietly changed who should AVOID the MMR vaccine.

https://www.cdc.gov/vaccines/vpd/mmr/public/index.html

They now state that ANYONE that “Has a parent, brother or sister with a history of immune system problems” should AVOID THE MMR VACCINE!

What exactly is an 'immune system problem?" Every autoimmune disorder.

* Achalasia

* Addison’s disease

* Adult Still's disease

* Agammaglobulinemia

* Alopecia areata

* Amyloidosis

* Amyotrophic lateral sclerosis (Lou Gehrigs)

* Ankylosing spondylitis

* Anti-GBM/Anti-TBM nephritis

* Antiphospholipid syndrome

* Autoimmune angioedema

* Autoimmune dysautonomia

* Autoimmune encephalomyelitis

* Autoimmune hepatitis

* Autoimmune inner ear disease (AIED)

* Autoimmune myocarditis

* Autoimmune oophoritis

* Autoimmune orchitis

* Autoimmune pancreatitis

* Autoimmune retinopathy

* Autoimmune urticaria

* Axonal & neuronal neuropathy (AMAN)

* Baló disease

* Behcet’s disease

* Benign mucosal pemphigoid

* Bullous pemphigoid

* Castleman disease (CD)

* Celiac disease

* Chagas disease

* Chronic inflammatory demyelinating polyneuropathy (CIDP)

* Chronic recurrent multifocal osteomyelitis (CRMO)

* Churg-Strauss Syndrome (CSS) or Eosinophilic Granulomatosis (EGPA)

* Cicatricial pemphigoid

* Cogan’s syndrome

* Cold agglutinin disease

* Congenital heart block

* Coxsackie myocarditis

* CREST syndrome

* Crohn’s disease

* Dermatitis herpetiformis

* Dermatomyositis

* Devic’s disease (neuromyelitis optica)

* Discoid lupus

* Dressler’s syndrome

* Endometriosis

* Eosinophilic esophagitis (EoE)

* Eosinophilic fasciitis

* Erythema nodosum

* Essential mixed cryoglobulinemia

* Evans syndrome

* Fibromyalgia

* Fibrosing alveolitis

* Giant cell arteritis (temporal arteritis)

* Giant cell myocarditis

* Glomerulonephritis

* Goodpasture’s syndrome

* Granulomatosis with Polyangiitis

* Graves’ disease

* Guillain-Barre syndrome

* Hashimoto’s thyroiditis

* Hemolytic anemia

* Henoch-Schonlein purpura (HSP)

* Herpes gestationis or pemphigoid gestationis (PG)

* Hidradenitis Suppurativa (HS) (Acne Inversa)

* Hypogammalglobulinemia

* IgA Nephropathy

* IgG4-related sclerosing disease

* Immune thrombocytopenic purpura (ITP)

* Inclusion body myositis (IBM)

* Interstitial cystitis (IC)

* Juvenile arthritis

* Juvenile diabetes (Type 1 diabetes)

* Juvenile myositis (JM)

* Kawasaki disease

* Lambert-Eaton syndrome

* Leukocytoclastic vasculitis

* Lichen planus

* Lichen sclerosus

* Ligneous conjunctivitis

* Linear IgA disease (LAD)

* Lupus

* Lyme disease chronic

* Meniere’s disease

* Microscopic polyangiitis (MPA)

* Mixed connective tissue disease (MCTD)

* Mooren’s ulcer

* Mucha-Habermann disease

* Multifocal Motor Neuropathy (MMN) or MMNCB

* Multiple sclerosis

* Myasthenia gravis

* Myositis

* Narcolepsy

* Neonatal Lupus

* Neuromyelitis optica

* Neutropenia

* Ocular cicatricial pemphigoid

* Optic neuritis

* Palindromic rheumatism (PR)

* PANDAS

* Parkinson's disease

* Paraneoplastic cerebellar degeneration (PCD)

* Paroxysmal nocturnal hemoglobinuria (PNH)

* Parry Romberg syndrome

* Pars planitis (peripheral uveitis)

* Parsonage-Turner syndrome

* Pemphigus

* Peripheral neuropathy

* Perivenous encephalomyelitis

* Pernicious anemia (PA)

* POEMS syndrome

* Polyarteritis nodosa

* Polyglandular syndromes type I, II, III

* Polymyalgia rheumatica

* Polymyositis

* Postmyocardial infarction syndrome

* Postpericardiotomy syndrome

* Primary biliary cirrhosis

* Primary sclerosing cholangitis

* Progesterone dermatitis

* Psoriasis

* Psoriatic arthritis

* Pure red cell aplasia (PRCA)

* Pyoderma gangrenosum

* Raynaud’s phenomenon

* Reactive Arthritis

* Reflex sympathetic dystrophy

* Relapsing polychondritis

* Restless legs syndrome (RLS)

* Retroperitoneal fibrosis

* Rheumatic fever

* Rheumatoid arthritis

* Sarcoidosis

* Schmidt syndrome

* Scleritis

* Scleroderma

* Sjögren’s syndrome

* Sperm & testicular autoimmunity

* Stiff person syndrome (SPS)

* Subacute bacterial endocarditis (SBE)

* Susac’s syndrome

* Sympathetic ophthalmia (SO)

* Takayasu’s arteritis

* Temporal arteritis/Giant cell arteritis

* Thrombocytopenic purpura (TTP)

* Tolosa-Hunt syndrome (THS)

* Transverse myelitis

* Type 1 diabetes

* Ulcerative colitis (UC)

* Undifferentiated connective tissue disease (UCTD)

* Uveitis

* Vasculitis

* Vitiligo

* Vogt-Koyanagi-Harada Disease

Wonder how many doctors are paying attention?

~shared from Jodi Wilson

[drnishargpatel]

Understanding the Long-Term Effects of Ulcerative Colitis

A chronic inflammatory bowel disease (IBD) that affects the colon (large intestine) and the rectum is called ulcerative colitis (UC). Many individuals get treatment to deal with their side effects, this medical condition can have lasting effects that affects many pieces of a person's life. The long term effects of the condition will be discussed in this article, with possible risk and the management techniques.

Effects of Chronic Inflammation

Inflammation over time in the colon causes long-term damage, which is one of the main concerns related to ulcerative colitis.

Risk of Colorectal Cancer: People who experienced UC for longer than 8 to 10 years are more likely to develop colorectal cancer due to ongoing inflammation of the colon.

Tissue Scarring: Prolonged inflammation can result in colon tissue scarring, which can lead to problems like strictures (colon constriction) and restrictive symptoms.

Severe Flare-ups: As UC progresses, a person's colon may enlarge rapidly and more frequently. This can result in challenges including toxic megacolon, a potentially fatal illness.

Effects on the Digestive Systems

Ulcerative colitis can cause major, long lasting changes to the digestive system.

Nutritional Deficiencies: Iron, calcium, and a lack of vitamin D can result from impaired nutrient caused by steady irritation and recurrent diarrhea.

Dehydration: UC patients frequently struggle with dehydration, especially during flare-ups, which can be set on by tireless diarrhea.

Changes in Bowel Function: Many UC patients could require a medical surgery to remove all or a part of their colon, which will modify their capacity to pass stool. The body's ability to control the digestion of water and supplements might be affected by this.

Systemic Health Improvement

Ulcerative colitis doesn't just affect the colon; it can also affect different regions of the body.

Joint pain (Joint Irritation): A great deal of people with UC experience joint inflammation, which brings side effects like joint inflammation.

Skin Conditions: UC can lead to skin issues like difficult red bumps known as erythema nodosum and ulcerative skin lesions called pyoderma gangrenosum.

Inflammation of the eye, like in uveitis and episcleritis, is more common in patients with ulcerative colitis.

Impact on the Brain and Heart

A constant sickness, for example, UC can negatively affect one's mental health.

Stress and Tension: Dealing with a condition with painful and unpleasant side effects that is unstable brings higher pressure and nervousness.

Depression: There is a higher possibility of creating depression because of the chronic nature of ulcerative colitis (UC) as well as expected limitations on everyday activity and interaction with others.

Body Image Issues: Certain people may have issues with their body image because of weight loss, actual look of their condition, or medical surgery, (for example, a colectomy or the requirement for a stoma).

Perspectives Affecting Quality of Life

An individual's personal satisfaction can be affected by UC in various areas of day to day existence.

Physical Restrictions: Exhaustion, continuous bowel movements, and pain during eruptions can cause limitations on actual work and create some issues for social or professional commitments.

Dietary Limitations: To control their side effects, many people with UC should stick to diets that reject explicit things that could cause eruptions.

Surgical Results: A colonoscopy, or the expulsion of the colon, might be important for specific UC patients at some point. This procedure can change a patient's bowel designs and require long lasting modifications.

Extended-Term Care and Therapy

Ulcerative colitis cannot be cured, long-term care can greatly enhance results.

Medication: Immunosuppressants, biologics, and anti-inflammatory meds are habitually used to reduce inflammation and treat side effects for an extended timeframe.

Continuous Monitoring: To follow the course of the condition and identify any possible issues, like colorectal disease, from the beginning, patients should have routine colonoscopies and other diagnostic testing.

Way of life Changes: Reducing pressure, eating a balanced diet, practising habitually, and stopping smoking are great ways of working on the side effects of ulcerative colitis (UC) and reducing its eruptions.

Don't forget to read our next article on''Ulcerative Colitis: Causes, Symptoms, and Key Factors."

There is something else to ulcerative colitis besides eruptions and side effect the board; it is a persistent sickness. Dr Nisarg patel best gastroenterologist in sids hospital surat, will give you the best advice and cure for your IBD issue. Patients and medical care experts can make better designs for decreasing complexities, upgrading personal satisfaction, and deflecting risks by having a better understanding of the disease's drawn out effects. Living with ulcerative colitis can be figured out how to consider a satisfying existence with the right care, checking, and lifestyle changes.

[wulfums]

my fucking pyoderma gangrenosum is back. im so fucking upset

basically its painful bad ulcers that smell really bad and its my body eating itself. i hate this i hate this

[fantailandfern]

Study day today 21.3.25

Arrived on campus late, so there weren't many seats left in the library, but I lucked out with this view. Autumn has definitely arrived. It's my favourite season - I love autumn colours, wearing tights and warmer clothes, and watching the world prepare for winter and rest.

Goal for today:

• finish last 3 modules of the course

[batwynn]

Autoimmune Antagonist

There’s something catastrophic In me that wants a new tattoo. Something eating from the inside out That remembers the million bee stings. That knows it would continue eating until limbs were lost Until the body was wholly gone. That creature begs for each scar to be eviscerated by needles. Branded by images over broken flesh. Fuck the consequences. Let my blood bleed with ink And the black and blue birds skitter across my stained bones.

[chiragglobalhospitals]

What is Ulcerative Colitis: A Comprehensive Summary

Ulcerative colitis (UC) is a chronic, inflammatory bowel disease (IBD) characterised by continuous inflammation of the colonic lining, beginning in the rectum and potentially extending proximally throughout the entire colon. UC is limited to the colon and involves only the superficial layers.

UC is a relapsing-remitting condition, meaning it alternates between periods of active disease (flares) and times of little or no symptoms (remission). Its onset can be gradual or sudden, and the severity can range from mild discomfort to life-threatening complications.

When your gut doesn’t feel good, nothing else feels right. Pain, bloating, and unpredictable bowel movements can make you feel helpless. It’s not just physical; it impacts your confidence, routines, and relationships. Many people live with chronic digestive discomfort without knowing that a condition like ulcerative colitis could be the cause, and that it’s treatable.

What are the symptoms of UC? How do I know if I have UC?

The clinical presentation of ulcerative colitis depends on the extent and severity of the disease. Symptoms may develop gradually or suddenly and may vary from person to person.

Intestinal Symptoms

Bloody diarrhoea: This is the hallmark symptom, often with mucus.

Abdominal pain: Commonly crampy and located in the lower left quadrant.

Urgency and pain during defecation: Sudden urge to defecate and a feeling of incomplete evacuation.

Increased frequency of bowel movements: Often more than six times per day during flares.

Passage of stools in sleep causes extreme discomfort and may disrupt sleep.

2. Generalised Symptoms

Fever

Fatigue

Weight loss

Anaemia: Due to chronic blood loss and inflammation.

3. Problems outside of the intestine:

UC is associated with systemic inflammation that can affect other organs:

Arthritis: Especially peripheral joints.

Uveitis and episcleritis: Eye inflammation.

Erythema nodosum and pyoderma gangrenosum: Skin manifestations.

Primary sclerosing cholangitis (PSC): A liver disease that can occur in association with UC.

Why did I get UC? What are the Causes and Risk Factors?

The exact cause of ulcerative colitis remains unknown. It is believed to be the result of a complex interplay of genetic, environmental, immune-related, and microbial factors.

Here are some key contributors:

Genetic Factors

Family history increases the risk significantly. First-degree relatives of individuals with UC are at a higher risk.

2. Immune System Dysfunction

UC is thought to be an autoimmune condition, where the immune system inappropriately attacks the lining of the colon.

3. Environmental Factors

Geography: More common in industrialised countries, particularly in North America and Northern Europe.

Diet: High-fat and high-sugar diets, low intake of fruits and vegetables, and excessive red meat consumption may increase risk.

Smoking: Interestingly, UC is less common in smokers. Some studies suggest that smoking may have a protective effect against UC.

Hygiene hypothesis: Overly sterile environments may lead to immune system dysregulation.

4. Gut bacteria

Alterations in the diversity and composition of intestinal bacteria (dysbiosis) have been noted in UC.

A reduction in beneficial bacteria and an increase in harmful species may contribute to inflammation.

How is Ulcerative Colitis Diagnosed?

The diagnosis of UC is based on a combination of clinical evaluation, laboratory tests, imaging, and endoscopic examination with biopsy.

Laboratory Tests

Complete blood count (CBC): May show anaemia or elevated white blood cell count.

C-reactive protein (CRP) and ESR: Markers of inflammation.

Fecal calprotectin: Elevated in intestinal inflammation.

2. Endoscopy

Colonoscopy with biopsy: The gold standard. Shows continuous inflammation beginning in the rectum. Biopsies confirm mucosal inflammation and rule out infections or dysplasia.

3. Imaging

Abdominal X-rays or CT scans: To assess complications like toxic megacolon or perforation.

Types of Ulcerative Colitis

UC is classified by the extent of colonic involvement:

Ulcerative proctitis: Inflammation limited to the rectum.

Left-sided colitis: Extends from the rectum to the splenic flexure.

Pancolitis: Involves the entire colon.

Do I need treatment for UC? Will I need surgery?

The goal of treatment is to induce and maintain remission, reduce symptoms, and improve quality of life. Therapy depends on disease severity and extent.

The main objective is to suppress inflammation, assist in healing, and sustain remission for as long as possible.

Conclusion

Ulcerative colitis can be a chronic condition, but it doesn’t have to dominate your life. With early diagnosis, an appropriate treatment regimen, and frequent medical check-ups, most individuals can successfully control their symptoms and lead a good quality of life.

Knowing your body, monitoring symptoms, and steering clear of personal triggers can help minimise flare-ups. From medication to diet to surgery, regular contact with your doctor is necessary to get appropriate care at any point.

If you have symptoms of ulcerative colitis or suspect you might, consult a Ulcerative Colitis Specialist at Chirag Hospitals to begin appropriate care.

Continue reading here to know more about: Ulcerative Colitis

[chronically-crying]

the most fucked part about having ptsd for me is having intrusive thoughts so intense just having to visualize it is as visceral as if i were actually doing it, like I was fidgeting with this key ring i keep on my water bottle, which I do ALL THE TIME, but for like four solid minutes I was convinced that if I did close to my face I would poke out my left eye. Sometimes I'll be sewing up holes in my clothes and I'll have to stop because I can't stop imagining what it would feel like to stab myself directly in my chronic wounds with the needle. it's usually not even a problem but like. when it is a problem, it's awful

[delveinsight12]

Psoriatic Arthritis Clinical Trials, Emerging Therapies, Key Companies | A Drug Pipeline Analysis Report 2024 | DelveInsight

DelveInsight’s 'Psoriatic Arthritis Pipeline Insight 2024' report provides comprehensive global coverage of available, marketed, and pipeline Psoriatic Arthritis therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the Psoriatic Arthritis pipeline domain.

Key Takeaways from the Psoriatic Arthritis Pipeline Report

Over 50+ Psoriatic Arthritis pipeline therapies are in various stages of development, and their anticipated acceptance in the Psoriatic Arthritis market would significantly increase market revenue. 

Leading Psoriatic Arthritis companies developing novel drug candidates to improve the Psoriatic Arthritis treatment landscape include AbbVie, and others.

Promising Psoriatic Arthritis pipeline therapies in various stages of development include ABT-494, Risankizumab, and others.

Psoriatic Arthritis Overview

Psoriatic Arthritis is a chronic inflammatory disease of the joints that can be associated with the psoriasis. It can affect both peripheral joints and axial skeleton causing pain, stiffness, swelling and joint destruction. This joint pathology develops gradually and cause more nuisance than disabling. 

Psoriatic arthritis is considered as seronegative spondyloarthropathies. The fact that it is Seronegative is that the blood tests negative for some factors that is present in rheumatoid arthritis. 

Spondyloarthropathy describes a group of conditions that all share common characteristics. First, there is a presence of arthritis that affects the spine. Second, inflammation occurs in ligaments, tendons and sometimes in other organs such as the eye.

Request for a sample report to know more about Psoriatic arthritis treatment algorithm and diagnosis.

Psoriatic Arthritis Pipeline Analysis: Drug Profile

Risankizumab: Abbvie

Risankizumab is an interleukin-23 (IL-23) inhibitor that selectively blocks IL-23 by binding to its p19 subunit. IL-23, a cytokine involved in inflammatory processes, is thought to be linked to a number of chronic immune-mediated diseases, including psoriasis.

Discover more about the emerging Psoriatic Arthritis drugs @ Psoriatic Arthritis Treatment Drugs

Psoriatic Arthritis Key Companies

AbbVie

Psoriatic Arthritis Pipeline Therapies

ABT-494

Risankizumab

Psoriatic Arthritis Pipeline Therapeutics Assessment

By development stage

By product type

By route of administration

By molecule type

By MOA type 

Scope of the Psoriatic Arthritis Pipeline Report 

Coverage: Global 

Key Psoriatic Arthritis Companies: AbbVie, and others

Key Psoriatic Arthritis Pipeline Therapies: ABT-494, Risankizumab, and others

Find out more about the Psoriatic Arthritis treatment options in development @ Psoriatic Arthritis Clinical Trials

Table of Contents

1. Introduction

2. Executive Summary

3. Overview

4. Pipeline Therapeutics

5. Late-Stage Products (Phase III)

6. Mid-Stage Products (Phase  II)

7. Early Stage Products (Phase  I/II)

8. Preclinical Stage Products

9. Discovery Stage Products

10. Therapeutic Assessment

11. Inactive Products

12. Collaborations Assessment- Licensing / Partnering / Funding

13. Unmet Needs

14. Market Drivers and Barriers

15. Appendix

16. About DelveInsight

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[contusmpublications]

Systemic Lupus Erythematosus in Patient with Pyoderma Gangrenosum: A CaseBased Literature Review

Abstract

Pyoderma Gangrenosum (PG) is a rare skin disorder that includes blisters, bullae, and ulcers, which can rapidly grow. Systemic Lupus Erythematosus (SLE) in association with PG is rarely reported, and the occurrence of PG earlier is relatively uncommon. A 33-year-old female patient known to have pyoderma gangrenosum presented with a 3-year history of polyarthralgia and morning stiffness involving both the hand and knee. She also complained of mouth ulcers, photophobia, fatigue, and sweating. Laboratory results disclosed anemia, leukopenia, and neutropenia. The autoimmune screen showed a positive ANA. Based on the clinical findings and positive immunologic studies, she was diagnosed with systemic lupus erythematosus. Initially, her general condition improved with an immunosuppressant, but the patient stopped her medication after three months of treatment. Although SLE is uncommon to develop after PG,

our case report shows that clinicians should consider it in any patient with a known history of PG who presents with obvious symptoms of an autoimmune disease.

Keywords: Systemic Lupus Erythematosus (SLE);

Pyoderma Gangrenosum (PG); Case Report

[desmoinesnewsdesk]

Pyoderma Gangrenosum Market to Show Incremental Growth During the Forecast Period 2032, Asserts DelveInsight | Companies – Johnson & Johnson, AbbVie, Amgen, Novartis, Eli Lilly and Company, Genentech

http://dlvr.it/SzB20d